gnomAD Consortium releases its first major studies of human genetic variation

For the last eight years, the Genome Aggregation Database (gnomAD) Consortium (and its predecessor, the Exome Aggregation Consortium, or ExAC), has been working with geneticists around the world to compile and study more than 125,000 exomes and 15,000 whole genomes from populations around the world. Now, in seven articles, gnomAD Consortium scientists describe their first […]

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Key components of proteins are twisted to boost reactions useful to medicine

In proteins, amino acids are held together by amide bonds. These bonds are long-lived and are robust against changes in temperature, acidity or alkalinity. Certain medicines make use of reactions involving amide bonds, but the bonds are so strong they actually slow down reactions, impeding the effectiveness of the medicines. Researchers devised a way to […]

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