Potential target for cardiac fibrosis treatment

A research team has identified a potential target for treating heart failure related to fibrosis. The study looked at an epigenetic ‘reader’ protein known as BRD4, showing that it serves a central role in regulating the activation of cardiac fibroblasts. They also found that chemical inhibitors of BRD4 potently block cardiac fibroblast activation. Source: Potential […]

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Gene editing enables researchers to correct mutation in muscle stem cells in DMD model

Duchenne muscular dystrophy (DMD) is a rare but devastating genetic disorder that causes muscle loss and physical impairments. Researchers have shown in a mouse study that the powerful gene editing technique known as CRISPR may provide the means for lifelong correction of the genetic mutation responsible for the disorder. Source: Gene editing enables researchers to […]

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Adaptation to life in cattle may be driving E. coli to develop harmful features

Research led by Kyushu University finds that E. coli from cattle share widespread genetic similarities with those that cause food poisoning in humans, indicating that the traits that are harmful to humans may emerge to improve survival in the bovine intestine. Source: Adaptation to life in cattle may be driving E. coli to develop harmful […]

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