Observed COVID-19 variability may have underlying molecular sources

People have different susceptibilities to SARS-CoV-2, the virus behind the COVID-19 pandemic, and develop varying degrees of fever, fatigue, and breathing problems — common symptoms of the illness. What might explain this variation? Scientists may have an answer to this mystery. Source: Observed COVID-19 variability may have underlying molecular sources

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Delivering proteins to testes could someday treat male infertility

According to the Mayo Clinic, about 15% of couples are infertile, and male infertility plays a role in over one-third of these cases. Often, problems with sperm development are to blame. Now, researchers have found a way to deliver a protein important for sperm cell production directly to mouse testicles, where it restored normal sperm […]

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Chili-shaped device could reveal just how hot that pepper is

Some people love spicy food — the hotter, the better. Others go out of their way to avoid the palate-singeing burn of capsaicin, the compound that gives chili peppers their kick. Now, researchers have developed a portable device (whimsically shaped like a chili pepper) that can reveal how much capsaicin a pepper contains, before biting […]

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Americans' responses to COVID-19 stay-home orders differed according to population density

Americans strongly reduced their visits to grocery stores, pharmacies, and transit stations following stay-at-home orders from mayors and governors earlier this year, but did not reduce their visits to parks and beaches. Source: Americans' responses to COVID-19 stay-home orders differed according to population density

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Transcription factors may inadvertently lock in DNA mistakes

A team of researchers has found that transcription factors have a tendency to bind strongly to ‘mismatched’ sections of DNA, i.e. sections of the genome that were not copied correctly. The strong binding of transcription factors to these mismatched sections of regulatory DNA might be a way in which random mutations become a problem that […]

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Scientists take major step toward Angelman Syndrome gene therapy

Babies born with a faulty maternal copy of the UBE3A gene will develop Angelman syndrome, a severe neurodevelopmental disorder with no cure and limited treatments. Now, for the first time, scientists show that gene editing and gene therapy techniques can be used to restore UBE3A in human neuron cultures and treat deficits in an animal […]

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