How molecular chaperones dissolve protein aggregates linked to Parkinson's disease

In many neurodegenerative diseases, proteins clump in the brain, forming so-called amyloid fibrils. Yet there exists a cellular defence mechanism that counteracts this process and even dissolves fibrils already formed. The mechanism is based on the activity of molecular helpers, so-called chaperones of the heat shock protein 70 family. Source: How molecular chaperones dissolve protein […]

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Former NFL players may not suffer more severe cognitive impairment than others, study indicates

Even though repeated hits to the head are common in professional sports, the long-term effects of concussions are still poorly understood. While many believe that professional athletes who experience multiple concussions will end up with severe cognitive impairment later in life, a new study suggests that may not necessarily be the case. Source: Former NFL […]

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DNA repair supports brain cognitive development

Researchers showed that na enzyme functions in genome maintenance by preventing double-stranded breaks in DNA during brain development in mice. In mice lacking this enzyme, these breaks occurred during epigenetic regulation of gene expression in the developing hippocampus, peaking two weeks after birth. The increased breaks were associated with abnormal neuronal dendrites and poor memory […]

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Prenatal thyroid hormones influence 'biological age' at birth

The environment we experience in early-life is known to have major consequences on later-life health and lifespan. A new study using an avian model suggests that increased prenatal exposure to maternal thyroid hormones could have beneficial effects on the ‘biological age’ at birth. Source: Prenatal thyroid hormones influence 'biological age' at birth

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Sleep loss hijacks brain's activity during learning

Sleep is crucial for consolidating our memories, and sleep deprivation has long been known to interfere with learning and memory. Now a new study shows that getting only half a night’s sleep – as many medical workers and military personnel often do – hijacks the brain’s ability to unlearn fear-related memories. That might put people […]

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