Archive for March, 2020

Experiments in mice and human cells shed light on best way to deliver nanoparticle therapy for cancer

Researchers in the cancer nanomedicine community debate whether use of tiny structures, called nanoparticles, can best deliver drug therapy to tumors passively — allowing the nanoparticles to diffuse into tumors and become held in place, or actively — adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the […]

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Urgent guidance, approach to identify patients at risk of drug-induced sudden cardiac death from use of off-label COVID-19 treatments

Some of the medications being used to treat COVID-19 are known to cause drug-induced prolongation of the QTc of some people. Patients with a dangerously prolonged QTc are at increased risk for potentially life-threatening ventricular rhythm abnormalities that can culminate in sudden cardiac death. A new study details more information about potential dangers and the […]

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How bacteria form communities on the human tongue

Using a recently developed fluorescent imaging technique, researchers in the United States have developed high-resolution maps of microbial communities on the human tongue. The images reveal that microbial biofilms on the surface of the tongue have a complex, highly structured spatial organization. Source: How bacteria form communities on the human tongue

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Development of a solid material capable of slowly releasing H2S and NO

Scientists have developed a solid material capable of slowly releasing hydrogen sulfide and nitric oxide when exposed to air. These gases can induce physiologically favorable effects at low concentrations (e.g., reducing inflammation and expanding blood vessels). However, their medical use has been limited due to difficulties in storing them and regulating their concentration. This material […]

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Teaching old transition metals new tricks: Chemists activate palladium catalysis by light

In the production of compounds, chemists have the goal of finding strategies that are most selective and avoid waste products. This helps to drive industrial innovation and drug development. In this context, a team of researchers has developed a new approach to so-called allyl functionalization. Source: Teaching old transition metals new tricks: Chemists activate palladium […]

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Commonly used mouthwash could make saliva significantly more acidic, change microbes

The first study looking at the effect of chlorhexidine mouthwash on the entire oral microbiome has found its use significantly increases the abundance of lactate-producing bacteria that lower saliva pH, and may increase the risk of tooth damage. “In the face of the recent COVID-19 outbreak many dentists are now using chlorhexidine as a pre-rinse […]

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Singapore modelling study estimates impact of physical distancing on reducing spread of COVID-19

A new modelling study conducted in a simulated Singapore setting has estimated that a combined approach of physical distancing interventions, comprising quarantine (for infected individuals and their families), school closure, and workplace distancing, is most effective at reducing the number of SARS-CoV-2 cases compared with other intervention scenarios included in the study. Source: Singapore modelling […]

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